反应详情

A soln. of 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (2.29 g, 9.19 mmol) in THF (30 ml) was added dropwise to a soln. of 2-methylaminoethanol (0.89 g, 0.95 ml, 11.8 mmol) and Et3N (5 ml) in THF (15 ml) at 0° C. The mixture was subsequently stirred at RT for 5 h and then concentrated i. vac., the residue was taken up in NaHCO3 soln. and the mixture was extracted with EtOAc (3×30 ml). The combined organic phases were dried with Na2SO4 and concentrated i. vac.

1. customat 0° C
2. concentrationconcentrated i
3. extractionand the mixture was extracted with EtOAc (3×30 ml)
4. dry with materialThe combined organic phases were dried with Na2SO4
5. concentrationconcentrated i