Sodium Thiosulfate → HCID 66701995, compound

HRID 424677Notes

Reaction equation

HRID 424677 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8](OO)=O)[CH:3]=1.C(S[C:20]1[N:25]=[C:24]([N:26]([CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:41])([CH3:40])[CH3:39])[S:27]([N:30]2[CH2:33][CH2:32][CH2:31]2)(=[O:29])=[O:28])[CH:23]=[C:22]([NH:42][C@H:43]([CH3:46])[CH2:44][OH:45])[N:21]=1)C1C=CC=CC=1.[S:47]([O-:51])([O-:50])(=O)=S.[Na+].[Na+]>C(Cl)Cl>[CH2:8]([S:47]([C:20]1[N:25]=[C:24]([N:26]([CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:39])([CH3:40])[CH3:41])[S:27]([N:30]2[CH2:31][CH2:32][CH2:33]2)(=[O:29])=[O:28])[CH:23]=[C:22]([NH:42][C@H:43]([CH3:46])[CH2:44][OH:45])[N:21]=1)(=[O:51])=[O:50])[C:4]1[CH:3]=[CH:2][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 66702006HCID 66702006, compound

Product 1

HCID 66701995HCID 66701995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

m-Chloroperbenzoic acid was added as a single portion to a solution of the subtitle product of step iii) (11.3 g) in DCM (500 ml) and stirred for 1 h. Saturated sodium thiosulfate solution (100 ml) was added and stirred vigourously until no peroxide was detected. The organics were separated and extracted with saturated sodium bicarbonate solution (200 ml) and brine (50 ml), dried (MgSO4) and concentrated to yield the subtitle compound as a crude solid. Yield: 10.9 g.

Workup

  1. customThe organics were separated
  2. extractionextracted with saturated sodium bicarbonate solution (200 ml) and brine (50 ml)
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-9acc81655e2a4baf8ae22636ef94916c
Source dataset
uspto-grants-2012_01
Patent number
US08106063B2

Reaction notes

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