Sodium Thiosulfate → HCID 66702087, compound

HRID 424680Notes

Reaction equation

HRID 424680 reaction equation
C(S[C:9]1[N:14]=[C:13]([N:15]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[C:11]([NH:28][C@H:29]([CH3:32])[CH2:30][OH:31])[N:10]=1)C1C=CC=CC=1.Cl[C:34]1[CH:39]=[CH:38][CH:37]=[C:36]([C:40](OO)=O)[CH:35]=1.[S:44]([O-:48])([O-:47])(=O)=S.[Na+].[Na+]>C(Cl)Cl>[CH2:40]([S:44]([C:9]1[N:14]=[C:13]([N:15]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:26])([CH3:27])[CH3:25])[S:16]([CH3:19])(=[O:17])=[O:18])[CH:12]=[C:11]([NH:28][C@H:29]([CH3:32])[CH2:30][OH:31])[N:10]=1)(=[O:48])=[O:47])[C:36]1[CH:35]=[CH:34][CH:39]=[CH:38][CH:37]=1

Participants

5

Reactant 3

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 66702109HCID 66702109, compound

Product 1

HCID 66702087HCID 66702087, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product of step ii) (6.8 g) in DCM (300 ml) was added m-chloroperbenzoic acid (8 g) at ambient temperature with stirring. After 6 h a concentrated solution of sodium thiosulphate (50 ml) was added and the organic phase collected. The organic phase was then washed with saturated sodium bicarbonate solution (×2) followed by brine. The organic phase was dried (MgSO4) and the solvent evaporated to leave the subtitle compound as a colourless foam. Yield: 7.0 g.

Workup

  1. customthe organic phase collected
  2. washThe organic phase was then washed with saturated sodium bicarbonate solution (×2)
  3. dry with materialThe organic phase was dried (MgSO4)
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-7fccca26abfb4042b3657a8635343cfb
Source dataset
uspto-grants-2012_01
Patent number
US08106063B2

Reaction notes

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