Trifluoroacetic acid → HCID 57833096, compound

HRID 424689Notes

Reaction equation

HRID 424689 reaction equation
[F:1][C:2]1[C:25]([CH3:26])=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH:9]=[C:8]([NH:17][C@H:18]([CH3:21])[CH2:19][OH:20])[N:7]=1.N[C:28](C)(C)CO.FC(F)(F)C(O)=O>>[F:1][C:2]1[C:25]([CH3:26])=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH:9]=[C:8]([NH:17][C:18]([CH3:28])([CH3:21])[CH2:19][OH:20])[N:7]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 118072-Amino-2-methyl-1-propanolHCID 57833112HCID 57833112, compound

Product 1

HCID 57833096HCID 57833096, compound

Procedure

The title compound was prepared as a white solid by the method of Example 115 using the subtitle product of Example 115 step (1.0 g), 2-amino-2-methyl-1 propanol (1.5 ml) and trifluoroacetic acid (2 ml). Yield: 0.19 g.

Sources & evidence

ORD record
ord-65438661eed044b19953d0a9870f5aaf
Source dataset
uspto-grants-2012_01
Patent number
US08106063B2

Reaction notes

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