反应详情

A solution of N-ethylpiperazine (5.0 g) and sulfamide (10.0 g) in 1,4-dioxane (100 ml) was stirred for 72 h at 110° C. The volatiles were removed in vacuo and 5 g of the residue was dissolved in methanol and applied to an SCX cartridge (70 g). The cartridge was washed with 50% aqueous methanol (200 ml) before the subtitle product was eluted with 10% triethylamine/methanol (100 ml) The solvent was removed under reduced pressure to yield the subtitle compound as a pale beige solid. Yield: 3.0 g.

1. customThe volatiles were removed in vacuo and 5 g of the residue
2. dissolutionwas dissolved in methanol
3. washThe cartridge was washed with 50% aqueous methanol (200 ml) before the subtitle product
4. washwas eluted with 10% triethylamine/methanol (100 ml) The solvent
5. customwas removed under reduced pressure