Hydrochloric Acid → 2-Azido-1,3-dichloro-benzene

Temperature

0 °C

A solution of 2,6-dichloroaniline (100 g, 617 mmol) in MTBE (1 L) is added via addition funnel over 30 minutes to commercial hydrogen chloride (600 mL). The white suspension is stirred 15 minutes and is cooled to 0° C. A solution of sodium nitrite (42.5 g, 617 mmol) in water (150 mL) is added dropwise via addition funnel. After stirring at 0° C. for 30 minutes, a solution of sodium azide (40.1 g, 617 mmol) in water (150 mL) is added. After the addition is completed (45 minutes), the mixture is stirred at 5-10° C. for 30 minutes. The reaction mixture is basified (pH 12) with 50% aq. NaOH, and is stirred for 30 more minutes. The phases are separated and the aqueous layer is extracted three times with MTBE. The combined organic layers are dried over magnesium sulfate and filtered. Toluene (1 L) is added to the organic layer and the solution is concentrated under reduced pressure to a volume of 760 mL to yield the title compound (115 g, 100% conversion, 0.8M solution) as a toluene solution. ES/MS m/e 188 (M+1).

1. stirringAfter stirring at 0° C. for 30 minutes
2. additionAfter the addition
3. custom(45 minutes)
4. stirringthe mixture is stirred at 5-10° C. for 30 minutes
5. stirringis stirred for 30 more minutes
6. customThe phases are separated
7. extractionthe aqueous layer is extracted three times with MTBE
8. dry with materialThe combined organic layers are dried over magnesium sulfate
9. filtrationfiltered
10. additionToluene (1 L) is added to the organic layer
11. concentrationthe solution is concentrated under reduced pressure to a volume of 760 mL

ORD record

ord-4bc1b4cbf7684a539bd7b63049022e02

Source dataset

uspto-grants-2012_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08106077B2