Methylamine → HCID 66703725, compound

HRID 425012Notes

Reaction equation

[C:1]([O:5][C:6](=[O:21])[NH:7][C@@H:8]([C@@H:18]1[CH2:20][O:19]1)[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])([CH3:4])([CH3:3])[CH3:2].[CH3:22][NH2:23]>>[C:1]([O:5][C:6](=[O:21])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])[C@@H:18]([OH:19])[CH2:20][NH:23][CH3:22])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 6329Methylamine

HCID 59786775HCID 59786775, compound

Product 1

HCID 66703725HCID 66703725, compound

Procedure

Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-(2,5-difluoro-phenyl)-ethyl]carbamic acid tert-butylester (0.17 g, 0.57 mmol) and methylamine (7 mL, 2M solution in methanol, 14 mmol; used as solvent) gives the title compound.

Sources & evidence

ORD record: ord-d7a7d0ebfc5f4f52bc300b1b08e00a01
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106090B2

Reaction notes

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