反应详情

温度

81.5 °C

25 g of N-{(R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)phenylamino]propyl}-5-chlorothiophene-2-carboxamide (X) are suspended at from 20 to 25° C. in 250 ml of toluene and admixed with 37.5 ml of 1-methyl-2-pyrrolidone and 11.9 g of N,N-carbonyldiimidazole. The reaction mixture is heated to from 80 to 83° C. for 20 minutes and subsequently heated to 115° C. for one hour. After cooling to 20° C., the precipitated reaction product is filtered off with suction, washed twice with 25 ml each time of water and dried at 60° C. under reduced pressure.

1. temperaturesubsequently heated to 115° C. for one hour
2. temperatureAfter cooling to 20° C.
3. customthe precipitated reaction product
4. filtrationis filtered off with suction
5. washwashed twice with 25 ml each time of water
6. customdried at 60° C. under reduced pressure