反应详情

According to the process of Example 1, except that the 2-thienylformamidine hydrochloride, 2-chloro-4-fluorobenzaldehyde and methyl acetoacetate were replaced by 2-furylformamidine hydrochloride, 2-chlorobenzaldehyde and ethyl acetoacetate, respectively, and 0.20 g of a pale yellow particulates were obtained (yield: 28%); 1H-NMR (400 MHz, CDCl3-d1) δ 7.45 (s, 1H, ArH); 7.37-7.34 (m, 2H, ArH); 7.20-7.10 (m, 2H, ArH); 6.48 (m, 1H, ArH); 6.09 (s, 1H, CH); 4.07-4.03 (q, 2H, J=7.2 Hz, CH2); 2.55 (s, 3H, CH3); 1.13-1.09 (t, 3H, J=7.2 Hz, CH3). MS (EI) 344.0 (M+).

1. customrespectively, and 0.20 g of a pale yellow particulates were obtained (yield: 28%)