Acetonitrile → HCID 672273, compound

HRID 425256Notes

Reaction equation

HRID 425256 reaction equation
[OH-].[K+].[NH2:3][C:4]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:5]=1[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.C(OCC)(=O)C.[C:25](#[N:27])[CH3:26]>>[NH2:27][C:25]1[CH:26]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]2[C:4](=[CH:17][CH:16]=[C:15]([Cl:18])[CH:14]=2)[N:3]=1

Participants

5

Reactant 4

HCID 6342Acetonitrile2×HCID 8857Ethyl AcetateHCID 128702-Amino-5-chlorobenzophenoneHCID 14797Potassium Hydroxide

Product 1

HCID 672273HCID 672273, compound

Procedure

A suspension of 1.4 g of powdered KOH in 25 ml of anhydrous acetonitrile stirred under an argon atmosphere was heated to boiling under reflux conditions for 30 minutes and then a solution of 1.15 g of 2-amino-5-chlorobenzophenone in 5 ml of anhydrous acetonitrile was added. The mixture was boiled with a reflux condenser for 12 hours. Cooling was followed by pouring into ice, extraction with ethyl acetate, washing with water and removal of the solvent by distillation.

Workup

  1. temperaturewas heated
  2. waitThe mixture was boiled with a reflux condenser for 12 hours
  3. temperatureCooling
  4. washwashing with water and removal of the solvent by distillation

Sources & evidence

ORD record
ord-7dc9ff98ac3644f5a21d8a9e0abb0b06
Source dataset
uspto-grants-2012_01
Patent number
US08106204B2

Reaction notes

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