Dimethylformamide → HCID 21111282, compound

HRID 425943Notes

Reaction equation

HRID 425943 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:20])([F:19])[F:18])[C:5]([NH2:8])=[N:6][CH:7]=1.[C:21]([C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1)([OH:23])=[O:22].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>[NH2:8][C:5]1[N:6]=[CH:7][C:2]([C:27]2[CH:28]=[CH:29][C:24]([C:21]([OH:23])=[O:22])=[CH:25][CH:26]=2)=[CH:3][C:4]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]([F:20])([F:19])[F:18]

Participants

7

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 3121834-Carboxyphenylboronic AcidHCID 21111495HCID 21111495, compound

Product 1

HCID 21111282HCID 21111282, compoundYield 69.4%

Reagents, catalysts & solvents 2

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 962WaterSolvent

Conditions

Temperature
87 °C

Procedure

5-Bromo-3-(2-trifluoromethyl-benzyloxy)-pyridin-2-ylamine (5.80 g, 16.7 mmol), 4-carboxybenzeneboronic acid (3.05 g, 18.4 mmol), tetrakis(triphenylphosphine)-palladium(0) (0.62 g, 0.6 mmol), potassium carbonate (8.10 g, 58 mmol), dimethylformamide (47 mL) and water (23 mL) were charged to a 250 mL three neck round bottom flask equipped with a thermometer, a reflux condenser and magnetic stirring. The mixture was purged with nitrogen and gradually heated from 81 to 93° C. over a period of 4 hr. Thin layer chromatography (ethyl acetate:hexane:acetic acid 4:6:0.5) showed product at Rf 0.6 and a few small impurities. The mixture was cooled to 45° C. The solids were collected by vacuum filtration, washed with 10 mL of ethanol:water 1:1 and discarded. The filtrate was diluted with 300 mL of water and 4 mL of 9 N potassium hydroxide solution (to pH 12-13), cooled in an ice bath and stirred for 30 minutes with 3 g of Celite and 3 g of Norit. The solids were collected by vacuum filtration through a pad of Celite and washed with 10 mL of water. The solids were discarded. The filtrate was cooled in an ice bath and acidified to pH 7.3 with acetic acid using a pH meter. The solids were collected by vacuum filtration, washed with 20 mL of ethanol:water 1:1 and dried under vacuum to give 4.5 g (69% yield) of 4-[6-amino-5-(2-trifluoromethyl-benzyloxy)-pyridin-3-yl]-benzoic acid as a brown solid.

Workup

  1. customequipped with a thermometer, a reflux condenser and magnetic stirring
  2. customThe mixture was purged with nitrogen
  3. temperatureThe mixture was cooled to 45° C
  4. filtrationThe solids were collected by vacuum filtration
  5. washwashed with 10 mL of ethanol:water 1:1
  6. additionThe filtrate was diluted with 300 mL of water and 4 mL of 9 N potassium hydroxide solution (to pH 12-13)
  7. temperaturecooled in an ice bath
  8. filtrationThe solids were collected by vacuum filtration through a pad of Celite
  9. washwashed with 10 mL of water
  10. temperatureThe filtrate was cooled in an ice bath
  11. filtrationThe solids were collected by vacuum filtration
  12. washwashed with 20 mL of ethanol:water 1:1
  13. customdried under vacuum

Sources & evidence

ORD record
ord-1f8e8bb1d60d4451a7857fcade6ea35d
Source dataset
uspto-grants-2012_01
Patent number
US08106197B2

Reaction notes

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