Water → HCID 57867979, compound

HRID 425986Notes

Reaction equation

HRID 425986 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[O:16]=[C:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19](=[O:26])N1C(OCC)=O.C(N(CC)CC)C.O>CN(C=O)C>[O:11]=[C:7]1[CH2:6][C:5]2[C:9](=[CH:10][C:2]([N:1]3[C:17](=[O:16])[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:19]3=[O:26])=[CH:3][C:4]=2[C:12]([F:15])([F:13])[F:14])[NH:8]1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31187N-CarbethoxyphthalimideHCID 23112254HCID 23112254, compound

Product 1

HCID 57867979HCID 57867979, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In DMF, 6-amino-4-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one and ethyl 1,3-dioxo-1,3-dihydro-2H-isoindol-2-carboxylate were allowed to undergo the reaction at 60° C. for 18 hours in the presence of triethylamine. Water was added to the reaction liquid and the resulting precipitate was collected by filtration to obtain 2-[2-oxo-4-(trifluoromethyl)-2,3-dihydro-1H-indol-6-yl]-1H-isoindol-1,3-(2H)-dione.

Workup

  1. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-517913af7710406fbeda078a0023766c
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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