1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 57867998, compound

HRID 425992Notes

Reaction equation

HRID 425992 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([NH:11][CH2:12][CH2:13][OH:14])[CH:3]=1.[NH2:15][C:16]1[CH:25]=[C:24]2[C:19]([CH2:20][CH2:21][C:22](=[O:27])[N:23]2[CH3:26])=[CH:18][CH:17]=1.Cl.C(N=C=NCCCN(C)C)C>ClCCl>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:15][C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][C:22](=[O:27])[N:23]3[CH3:26])=[CH:18][CH:17]=2)=[O:8])=[C:4]([NH:11][CH2:12][CH2:13][OH:14])[CH:3]=1

Participants

5

Reactant 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 212519912-(2-hydroxyethylamino)-4-chlorobenzoic AcidHCID 336993947-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 57867998HCID 57867998, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In dichloromethane, a mixture of 4-chloro-2-[(2-hydroxyethyl)amino]benzoic acid and 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one was treated with 1-ethyl-3-[3-(N,N-dimethylamino)propyl]carbodiimide hydrochloride at room temperature to obtain 4-chloro-2-[(2-hydroxyethyl)amino]-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)benzamide.

Sources & evidence

ORD record
ord-2ba44da51ec24b71bc756c522d672880
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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