Potassium Iodide → HCID 57867977, compound

HRID 425997Notes

Reaction equation

HRID 425997 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][C:10](=[O:14])[NH:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Br[CH2:16][CH2:17][O:18][Si:19]([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C=O)C.O>[Si:19]([O:18][CH2:17][CH2:16][N:11]1[C:12]2[C:7](=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:13]=2)[CH2:8][CH2:9][C:10]1=[O:14])([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20]

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilaneHCID 19094726HCID 19094726, compound

Product 1

HCID 57867977HCID 57867977, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

7-Nitro-3,4-dihydroquinolin-2(1H)-one, (2-bromoethoxy)(tert-butyl)dimethylsilane, potassium carbonate, potassium iodide and water were added to DMF, followed by stirring at room temperature for 2 days and then stirred at 40° C. for 3 days. By post-treating the reaction liquid, 1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-7-nitro-3,4-dihydroquinolin-2(1H)-one was obtained.

Workup

  1. stirringstirred at 40° C. for 3 days
  2. additionBy post-treating
  3. customthe reaction liquid

Sources & evidence

ORD record
ord-4f0e654baf2f49648344bf8f36f45762
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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