Pyridine → HCID 15851621, compound

HRID 426001Notes

Reaction equation

HRID 426001 reaction equation
N1C=CC=CC=1.FC(F)(F)C(OC(=O)C(F)(F)F)=O.[C:20]([C:24]1[CH:32]=[CH:31][C:27]([C:28]([NH2:30])=O)=[C:26]([F:33])[CH:25]=1)([CH3:23])([CH3:22])[CH3:21]>O1CCOCC1>[C:20]([C:24]1[CH:32]=[CH:31][C:27]([C:28]#[N:30])=[C:26]([F:33])[CH:25]=1)([CH3:23])([CH3:21])[CH3:22]

Participants

5

Reactant 3

HCID 1049PyridineHCID 9845Trifluoroacetic anhydrideHCID 57614568HCID 57614568, compound

Product 1

HCID 15851621HCID 15851621, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Pyridine and trifluoroacetic anhydride were added to a dioxane solution of 4-tert-butyl-2-fluorobenzamide and stirred at room temperature for 3 hours. By post-treating the reaction liquid, 4-tert-butyl-2-fluorobenzonitrile was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-7254907d12dc45c6958d77ac282f314e
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

Loading…