Triphenylphosphine → HCID 59364377, compound

HRID 426043Notes

Reaction equation

HRID 426043 reaction equation
[N:1]([CH2:4][CH2:5][O:6][CH:7]([C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[CH3:26])[CH2:8][CH2:9][N:10]([CH3:18])[C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[N+]=[N-].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>C1COCC1.O>[NH2:1][CH2:4][CH2:5][O:6][CH:7]([C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[CH3:26])[CH2:8][CH2:9][N:10]([CH3:18])[C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:14])[CH3:15]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 86642386HCID 86642386, compound

Product 1

HCID 59364377HCID 59364377, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

tert-Butyl 3-(2-azidoethoxy)-3-(5-chloro-2-methylphenyl)propyl(methyl)carbamate (270 mg, 0.707 mmol) was dissolved in THF/H2O (5 mL, 20:1), PPh3 (741 mg, 2.83 mmol) was added in portions. The reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo and used without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customused without further purification

Sources & evidence

ORD record
ord-a96dd74904254b77966649f338a2b52d
Source dataset
uspto-grants-2012_01
Patent number
US08106221B2

Reaction notes

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