Phenol → HCID 4496358, compound

HRID 426437Notes

Reaction equation

HRID 426437 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH:15]([CH3:21])[C:16]([O:18][CH2:19][CH3:20])=[O:17]>C(O)C>[O:7]([CH:15]([CH3:21])[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 996PhenolHCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionate

Product 1

HCID 4496358HCID 4496358, compoundYield 61.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture consisting of 34.8 gm (0.37 mol) of phenol, 111 gm (0.81 mol) of potassium carbonate, 89 ml (0.69 mol) of ethyl 2-bromo-propionate and 200 ml of ethanol was boiled for 12 hours, while stirring. Thereafter, the reaction mixture was filtered, and the filtrate was distilled, yielding 44.2 gm of ethyl 2-phenoxy-propionate, b.p. 93°-94° C. at 0.1 mm Hg.

Workup

  1. filtrationThereafter, the reaction mixture was filtered
  2. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-399e58bbba784978be25fe6486206bf2
Source dataset
uspto-grants-1979_10
Patent number
US04169720

Reaction notes

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