反应详情

A solution of 988 mg of the crude material prepared in Example XV in 7.5 ml dry acetone was stirred at 25° under argon with 1.80 gm lithium bromide for 18.25 hours at 25°. The acetone was removed in vacuo and water added to the residue. The mixture was extracted with 95:5 hexaneether. The extracts were washed with 10% aqueous sodium thiosulfate and brine, dried over MgSO4, filtered and evaporated in vacuo to afford 737 mg of a yellow oil having the following structure: ##STR39##

1. customThe acetone was removed in vacuo and water
2. additionadded to the residue
3. extractionThe mixture was extracted with 95:5 hexaneether
4. washThe extracts were washed with 10% aqueous sodium thiosulfate and brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated in vacuo