Lithium Bromide → HCID 20389720, compound

HRID 426700Notes

Reaction equation

HRID 426700 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[C:14](=[O:18])[CH2:15][CH2:16][CH:17]=1)(=O)=O.[Br-:19].[Li+]>CC(C)=O>[Br:19][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[C:14](=[O:18])[CH2:15][CH2:16][CH:17]=1

Participants

4

Reactant 2

HCID 82050Lithium BromideHCID 20389669HCID 20389669, compound

Product 1

HCID 20389720HCID 20389720, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 988 mg of the crude material prepared in Example XV in 7.5 ml dry acetone was stirred at 25° under argon with 1.80 gm lithium bromide for 18.25 hours at 25°. The acetone was removed in vacuo and water added to the residue. The mixture was extracted with 95:5 hexaneether. The extracts were washed with 10% aqueous sodium thiosulfate and brine, dried over MgSO4, filtered and evaporated in vacuo to afford 737 mg of a yellow oil having the following structure: ##STR39##

Workup

  1. customThe acetone was removed in vacuo and water
  2. additionadded to the residue
  3. extractionThe mixture was extracted with 95:5 hexaneether
  4. washThe extracts were washed with 10% aqueous sodium thiosulfate and brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. customevaporated in vacuo

Sources & evidence

ORD record
ord-4998cd25aca3438aa2d1aa840bd19db9
Source dataset
uspto-grants-1979_10
Patent number
US04171331

Reaction notes

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