Hydrochloric Acid → HCID 20389894, compound

HRID 426740Notes

Reaction equation

HRID 426740 reaction equation
[Cl:1][C:2]1([N+:9]([O-])=O)[CH2:6][N:5]([CH3:7])[N:4]=[C:3]1[CH3:8].[ClH:12].[H][H]>[Pt].CO>[ClH:1].[NH2:9][C:2]1[C:3]([CH3:8])=[N:4][N:5]([CH3:7])[C:6]=1[Cl:12]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 20389895HCID 20389895, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20389894HCID 20389894, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

4-Chloro-1,3-dimethyl-4-nitropyrazole (described in U.S. Pat. No. 3,282,954) (70.0 g.) was dissolved in 900 ml. methanol and 68 ml. concentrated HCl and hydrogenated over 3.2 g. platinum on carbon. After the hydrogen uptake ceased, the catalyst was filtered, the solvent concentrated in vacuum and the residue crystallized from isopropyl alcohol to get 64.15 g. of product, mp 234°-235° C., decomposed.

Workup

  1. dissolution3,282,954) (70.0 g.) was dissolved in 900 ml
  2. filtrationthe catalyst was filtered
  3. concentrationthe solvent concentrated in vacuum
  4. customthe residue crystallized from isopropyl alcohol
  5. customto get 64.15 g

Sources & evidence

ORD record
ord-369f2a85df0845fd9012422121698354
Source dataset
uspto-grants-1979_10
Patent number
US04171367

Reaction notes

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