HRID426975

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1nnc(SCC2=C(C(=O)O)N3C(=O)C(N)[C@H]3SC2)s1

HCID12942034

未命名化合物

HCID20297199

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1

HCID441328

7-Aminocephalosporanic acid

C10H12N2O5S

结构：Cc1nnc(SCC2=C(C(=O)O)N3C(=O)C(NC(=O)CS(=O)c4ccccn4)[C@H]3SC2)s1

HCID131711648

未命名化合物

PROCEDURE

实验过程

Procedures of Example 10 were repeated by using 2-pyridylsulfinylacetic acid and 7-amino-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid instead of the 4-pyridylsulfinylacetic acid and the 7-aminocephalosporanic acid respectively to obtain 7-(2-pyridylsulfinylacetamido)-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid of the R form.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-531c6074c9d1415fa30f9eab410931fe
来源数据集: uspto-grants-1979_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04172197
来源说明: uspto-grants-1979_10

反应 SMILES

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([CH2:9][C:10]([OH:12])=[O:11])=[O:8].[NH2:13][CH:14]1[C:32](=[O:33])[N:16]2[C:17]([C:29]([OH:31])=[O:30])=[C:18]([CH2:21][S:22][C:23]3[S:27][C:26]([CH3:28])=[N:25][N:24]=3)[CH2:19][S:20][C@H:15]12>>[CH3:9][C:10]([O:12][CH2:21][C:18]1[CH2:19][S:20][C@@H:15]2[C@H:14]([NH2:13])[C:32](=[O:33])[N:16]2[C:17]=1[C:29]([OH:31])=[O:30])=[O:11].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([CH2:9][C:10]([NH:13][CH:14]1[C:32](=[O:33])[N:16]2[C:17]([C:29]([OH:31])=[O:30])=[C:18]([CH2:21][S:22][C:23]3[S:27][C:26]([CH3:28])=[N:25][N:24]=3)[CH2:19][S:20][C@H:15]12)=[O:12])=[O:8]