O-Methylhydroxylamine hydrochloride → 3-(4,5-Diphenyl-oxazol-2-yl)-propionaldehyde O-methyl-oxime

HRID 42713Notes

Reaction equation

HRID 42713 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][CH:20]=O)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:23][O:24][NH2:25]>>[CH3:23][O:24][N:25]=[CH:20][CH2:19][CH2:18][C:9]1[O:10][C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 133100023-(4,5-Diphenyl-1,3-oxazol-2-yl)propanal

Product 1

HCID 768004183-(4,5-Diphenyl-oxazol-2-yl)-propionaldehyde O-methyl-oxime

Procedure

The process described in Method A was followed. 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanal (554 mg, 2.0 mmol, see Pridgen L. N. et al in Tetrahedron Lett., 25(27), 2835 (1984)) and methoxyamine hydrochloride (222 mg, 2.66 mmol) were used to obtain the title compound.

Sources & evidence

ORD record
ord-d3f499d80d1d4768a2e6ec084f8a5946
Source dataset
uspto-grants-2013_09
Patent number
US08536210B2

Reaction notes

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