Methanol → HCID 18356781, compound

HRID 427240Notes

Reaction equation

HRID 427240 reaction equation
[Na].Cl[C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:6]=[C:5]([S:19][CH3:20])[N:4]=1.[CH3:21][OH:22]>>[CH3:20][S:19][C:5]1[N:4]=[C:3]([O:22][CH3:21])[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:6]=1

Participants

4

Reactant 3

HCID 887Methanol2×HCID 5360545SodiumHCID 18356786HCID 18356786, compound

Product 1

HCID 18356781HCID 18356781, compound

Procedure

A solution of 0.38 g sodium in 50 ml methanol are added to 4.6 g of the compound from example 4 in 75 ml methanol at room temperature. After stirring over night the mixture is evaporated, re-dissolved in dichloro-methane and filtered to give 4.1 g of the title product (m.p. 82-84° C.).

Workup

  1. customis evaporated
  2. dissolutionre-dissolved in dichloro-methane
  3. filtrationfiltered

Sources & evidence

ORD record
ord-7f09debdf4d840fcae70f27483ab3add
Source dataset
uspto-grants-2001_11
Patent number
US06313072B1

Reaction notes

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