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HRID427302

反应详情

EQUATION

反应方程式

HRID 427302 的结构方程式

REACTANTS

反应物

2
结构：Cn1ncc(C#N)c1N
HCID219740

5-amino-1-methyl-1H-pyrazole-4-carbonitrile

C5H6N4

结构：COc1ccc(C(=O)Oc2ccc([N+](=O)[O-])cc2)c2sc(C3CC3)nc12
HCID69690690

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C(=O)Nc2c(C#N)cnn2C)c2sc(C3CC3)nc12
HCID9903187

未命名化合物

收率 49.8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：C[Si](C)(C)[N-][Si](C)(C)C.[Na+]
溶剂HCID2724254

Sodium bis(trimethylsilyl)amide

C6H18NNaSi2

PROCEDURE

实验过程

Starting from 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (90 mg) in dimethyl formamide (30 ml), sodium hexamethyldisilazide in tetrahydrofbran (1.08 ml, 1.0 M), and 2-cyclopropyl-4-methoxybenzothiazole-7-carboxylic acid 4-nitrophenyl ester (200 mg). Purification by flash chromatography (eluent 10% methanol in dichloromethane) to yield the title compound as an off-white solid (95 mg). TLC Rf 0.30 (10% methanol in dichloromethane); Mpt 259-260° C.

WORKUP

后处理

  1. customPurification by flash chromatography (eluent 10% methanol in dichloromethane)