Isobutylamine → HCID 28165295, compound

HRID 427361Notes

Reaction equation

HRID 427361 reaction equation
[NH:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[C@H:2]([C:6]([OH:8])=O)[CH:3]([CH3:5])[CH3:4].[CH2:16]([NH2:20])[CH:17]([CH3:19])[CH3:18].C1C=CC2N(O)N=NC=2C=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C=O)C>[NH:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[C@H:2]([C:6]([NH:20][CH2:16][CH:17]([CH3:19])[CH3:18])=[O:8])[CH:3]([CH3:4])[CH3:5]

Participants

6

Reactant 4

HCID 6558IsobutylamineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 83693Boc-L-Valine

Product 1

HCID 28165295HCID 28165295, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a DMF solution containing 2.0 g of Boc-Val-OH, 0.92 ml of isobutylamine, 1.40 g of HOBt and 2.28 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 51 (Process 1) to give 1.89 g of the title compound.

Workup

  1. additionwere added under ice cooling
  2. additionThe reaction mixture was treated similarly to that in Example 51 (Process 1)

Sources & evidence

ORD record
ord-ae17d9a5403d4cada7cfb0e46a1a1284
Source dataset
uspto-grants-2001_11
Patent number
US06313094B1

Reaction notes

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