1-Hydroxybenzotriazole → HCID 101051613, compound

HRID 427367Notes

Reaction equation

HRID 427367 reaction equation
[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=O.[CH2:16]([NH2:21])[C:17]([CH3:20])([CH3:19])[CH3:18].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.Cl>CN(C=O)C>[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([NH:21][CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:5]

Participants

6

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 79882NeopentylamineHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 101051613HCID 101051613, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a DMF solution containing 1.00 g of Boc-Pro-OH, 0.58 ml of neopentylamine, 0.71 g of HOBt and 1.06 g of EDC hydrochloride were added and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 30 (Process 3) to give 605 mg of the title compound.

Workup

  1. additionwere added
  2. additionThe reaction mixture was treated similarly to that in Example 30 (Process 3)

Sources & evidence

ORD record
ord-9326d4c2bd0d48f080a31a8e4dacf85a
Source dataset
uspto-grants-2001_11
Patent number
US06313094B1

Reaction notes

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