反应详情

To a solution of 1-bromo-2-isopropyl-6-methylbenzene (6.9 g, 32.4 mmol) in diethyl ether (50 ml) was added magnesium turnings (0.9 g, 37 mmol) and the mixture was refluxed in nitrogen atmosphere until the reaction was started and was then stirred overnight at room temperature. Dimethylformamide (4 ml) was added dropwise during 10 min. and the mixture was stirred for 30 min. Saturated ammmoniumchloride solution (30 ml) was added and the mixture was stirred for 1 h. The organic layer was separated, filtrated and evaporated under reduced pressure. Purification by column chromatography on silica gel using hexane:methylene chloride (3:2) as eluent gave 1.75 g (33%) of the title compound .

1. temperaturethe mixture was refluxed in nitrogen atmosphere until the reaction
2. stirringthe mixture was stirred for 30 min
3. stirringthe mixture was stirred for 1 h
4. customThe organic layer was separated
5. filtrationfiltrated
6. customevaporated under reduced pressure
7. customPurification by column chromatography on silica gel