反应详情

To a solution of 3-amino-2-indolecarboxylic acid ethyl ester (500 mg, 2.45 mmol) and triethylamine (272 mg, 2.70 mmol) in methylene chloride (5 mL) was added anisoyl chloride (418 mg, 2.45 mmol). The resulting mixture was stirred for 18 h at room temperature. The reaction mixture was diluted with ethyl acetate and washed with water. The organic phase was washed with 1 N aqueous hydrochloric acid, dried (sodium sulfate), filtered, and concentrated in vacuo to provide a yellow solid. Recrystallization from hexane/ethyl acetate provided 780 mg (94%) of the title compound as a yellow solid.

1. washwashed with water
2. washThe organic phase was washed with 1 N aqueous hydrochloric acid
3. dry with materialdried (sodium sulfate)
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customto provide a yellow solid
7. customRecrystallization from hexane/ethyl acetate