Hydrochloric Acid → HCID 70245021, compound

HRID 428125Notes

Reaction equation

HRID 428125 reaction equation
[C:1](/[C:3](=[CH:19]\[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)/[C:4]([NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15]COC)=[CH:11][CH:10]=1)=[O:5])#[N:2].[ClH:26]>CO.C(O)C>[ClH:26].[C:1](/[C:3](=[CH:19]\[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)/[C:4]([NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)=[O:5])#[N:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 12051145HCID 12051145, compound

Product 1

HCID 70245021HCID 70245021, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

(E)-2-cyano-N-(4-methoxymethoxyphenethyl)-3-(3-pyridyl)-2-propenoic acid amide (0.81 g, 2.4 mmol) obtained in Example 1 was dissolved in a mixed solution of methanol (10 ml) and ethanol (10 ml) and concentrated hydrochloric acid (0.3 ml) was added and stirred for 3 days. The precipitated crystal was filtered and washed with ether to yield the titled compound (0.57 g, 72%).

Workup

  1. additionwas added
  2. filtrationThe precipitated crystal was filtered
  3. washwashed with ether

Sources & evidence

ORD record
ord-64876ae039f84016965676db4bb0541e
Source dataset
uspto-grants-2001_11
Patent number
US06313153B1

Reaction notes

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