反应详情

A mixture of methyl trans-3-(3-pyridyl)acrylate (326 mg), 3,4-dimethoxy-N-methylphenethylamine (390 mg), 60% sodium hydride (80 mg) and diethylene glycol dimethyl ether (2 ml) was stirred at room temperature for 24 hours. Water was added to the reaction mixture, extracted with ethyl acetate, washed with water and dried over magnesium sulfate. After the solvent was distilled out under reduced pressure, the residue was purified by silica gel column chromatography (chloroform:methanol=50:1) and recrystallized to yield the titled compound (278 mg, 43%).

1. extractionextracted with ethyl acetate
2. washwashed with water
3. dry with materialdried over magnesium sulfate
4. distillationAfter the solvent was distilled out under reduced pressure
5. customthe residue was purified by silica gel column chromatography (chloroform:methanol=50:1)
6. customrecrystallized