反应详情

To isopropanol (200 ml), 40% aqueous methylamine solution (133 ml) was added and stirred under ice-cooling. 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone (8.47 g, 33 mmol) was dissolved in isopropanol (10 ml) and dichloromethane (10 ml) and dropwise added to the reaction mixture over 1 hour. After the dropwise addition, the mixture was stirred for 15 minutes under ice-cooling. The solvent in the reaction mixture was distilled out at room temperature under reduced pressure and the precipitated crystal was filtered to yield 1-(3,4-dimethoxyphenyl)-2-(methylamino)ethanone hydrobromide (6.36 g, 67%).

1. temperaturecooling
2. additionAfter the dropwise addition
3. stirringthe mixture was stirred for 15 minutes under ice-
4. temperaturecooling
5. distillationThe solvent in the reaction mixture was distilled out at room temperature under reduced pressure
6. filtrationthe precipitated crystal was filtered