2-Bromoanisole → HCID 178506687, compound

HRID 428344Notes

Reaction equation

HRID 428344 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1Br.[Li:10]CCCC>C(OCC)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Li:10]

Participants

4

Reactant 2

HCID 113582-BromoanisoleHCID 178418339Butyllithium

Product 1

HCID 178506687HCID 178506687, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
-78 °C

Procedure

2-Methoxybromobenzene (8.44 g 45.1 mmol) was dissolved in dry diethyl ether (15 mL). The mixture was cooled to −78° C. n-BuLi (17.8 mL, 45.0 mmol) was added and the mixture was stirred for one hour at −78° C. and then for 20 min. at −10° C. The aryl lithium solution was used immediately.

Workup

  1. additionwas added
  2. waitfor 20 min. at −10° C

Sources & evidence

ORD record
ord-6666370064c74dedb7598c8ceddabd33
Source dataset
uspto-grants-2001_11
Patent number
US06313132B1

Reaction notes

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