HRID428361

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID90235

4-Amino-2-chloro-6,7-dimethoxyquinazoline

C10H10ClN3O2

HCID2734641

1-(Tetrahydro-2-furoyl)piperazine

C9H16N2O2

PRODUCTS

生成物

结构：COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC.Cl

HCID44383

Terazosin hydrochloride

C19H26ClN5O4

收率 73.3%

PROCEDURE

实验过程

The procedures of Example 9 were followed except that Compound 3 from Example 1 (3.0 grams, 16.3 mmole) and 4-amino-2-chloro-6,7-bismethoxy quinazoline III (3.8 grams, 16.1 mmole) were reacted to obtain 5.0 grams of Terazosin hydrochloride (Yield: 73%). After alkalification, 4.7 grams of white Terazosin solid was obtained.

WORKUP

后处理

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