Ethanol → HCID 178466014, compound

HRID 428621Notes

Reaction equation

HRID 428621 reaction equation
[NH:1]1[CH:5]=[C:4]([CH:6]2[C:14]3[C:9](=[C:10]([CH3:18])[C:11]([CH3:17])=[C:12]([O:15][CH3:16])[CH:13]=3)[CH:8]([OH:19])[CH2:7]2)[N:3]=[CH:2]1.[CH2:20](O)[CH3:21]>Cl>[CH2:20]([O:19][CH:8]1[C:9]2[C:14](=[CH:13][C:12]([O:15][CH3:16])=[C:11]([CH3:17])[C:10]=2[CH3:18])[CH:6]([C:4]2[N:3]=[CH:2][NH:1][CH:5]=2)[CH2:7]1)[CH3:21]

Participants

4

Reactant 2

HCID 702EthanolHCID 178486576HCID 178486576, compound

Product 1

HCID 178466014HCID 178466014, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
25 °C

Procedure

3-(1H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-ol (cis-isomer, 0.1 g) is dissolved in the mixture of ethanol (20 ml) and concentrated hydrochloric acid (2 ml). The solution is stirred at 25° C. for one hour. Work-up of the reaction mixture gives the crude product, which is purified by flash chromatography using methylene chloride-methanol as eluent.

Sources & evidence

ORD record
ord-c36feb504b8a4257a74929483c6ccdd0
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

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