Hydrogen Bromide → HCID 178515465, compound

HRID 428625Notes

Reaction equation

HRID 428625 reaction equation
Cl.C[O:3][C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][CH:10]2[CH2:13][C:14]2[N:15]=[CH:16][NH:17][CH:18]=2)=[CH:6][CH:5]=1.Br.[OH-].[NH4+]>O>[NH:17]1[CH:18]=[C:14]([CH2:13][CH:10]2[C:11]3[C:7](=[CH:6][CH:5]=[C:4]([OH:3])[CH:12]=3)[CH2:8][CH2:9]2)[N:15]=[CH:16]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 14923Ammonium HydroxideHCID 178487127HCID 178487127, compound

Product 1

HCID 178515465HCID 178515465, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred mixture of 4-(6-methoxyindan-1-ylmethyl)-1H-imidazole hydrochloride (140 mg) and 48% hydrobromic acid (7 ml) is heated under reflux for 45 minutes. The cooled reaction mixture is poured into water and is made basic with ammonium hydroxide solution. The product is extracted into ethyl acetate which is washed with water, dried with sodium sulfate and evaporated to dryness. The crude product is coverted to its hydrochloride salt in ethyl acetate. M.p. 206-208° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 45 minutes
  3. customThe cooled reaction mixture
  4. extractionThe product is extracted into ethyl acetate which
  5. washis washed with water
  6. dry with materialdried with sodium sulfate
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-10d39b311a244df19c5f36177a3297a8
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

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