3-Pyridinecarboxaldehyde → 3-Pyridinemethanol,alpha-ethynyl-(9CI)
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[O:8])[CH:2]=1.[C:9]([Mg]Cl)#[CH:10]>C1COCC1>[OH:8][CH:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:9]#[CH:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Hydroxy-3-(3-pyridinyl)-1-propyne was prepared according to Method A above using 3-pyridine carboxaldehyde (0.428 g, 4 mmol) (Aldrich) in THF (20 mL) and ethynylmagnesium chloride (5 mmol, 10 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 440 mg, 83%).
Sources & evidence
- ORD record
- ord-de9aacbfb5174ba1a9b4dd91f8625ba1
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06313310B1
Reaction notes
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