Pyrrole-2-carboxaldehyde → HCID 18359225, compound

HRID 428676Notes

Reaction equation

HRID 428676 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[O:7].[C:8]([Mg]Cl)#[CH:9]>C1COCC1>[OH:7][CH:6]([C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)[C:8]#[CH:9]

Participants

4

Reactant 2

HCID 13854Pyrrole-2-carboxaldehydeHCID 178462451HCID 178462451, compound

Product 1

HCID 18359225HCID 18359225, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Hydroxy-3-(1H-pyrrol-2-yl)-1-propyne was prepared by Method B above using 2-pyrrolecarboxaldehyde (0.389 g, 4 mmol) (Aldrich) in THF (30 mL) and ethynylmagnesium chloride (20 mmol, 40 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 345 mg, 82%).

Sources & evidence

ORD record
ord-012c755928cb43829973a2e8b896ed9d
Source dataset
uspto-grants-2001_11
Patent number
US06313310B1

Reaction notes

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