Isovanillin → HCID 18359237, compound

HRID 428680Notes

Reaction equation

HRID 428680 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=[O:6].[C:12]([Mg]Cl)#[CH:13]>C1COCC1>[OH:6][CH:5]([C:4]1[CH:7]=[CH:8][C:9]([O:10][CH3:11])=[C:2]([OH:1])[CH:3]=1)[C:12]#[CH:13]

Participants

4

Reactant 2

HCID 12127IsovanillinHCID 178462451HCID 178462451, compound

Product 1

HCID 18359237HCID 18359237, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1-propyne was prepared according to Method B above from 3-hydroxy-4-methoxybenzaldehyde (0.304 g, 2 mmol) (Aldrich) in THF (20 mL) and ethynylmagnesium chloride (5 mmol, 10 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 273 mg, 77%).

Sources & evidence

ORD record
ord-88f0a6109bed4b868483f6d1c3e5cd10
Source dataset
uspto-grants-2001_11
Patent number
US06313310B1

Reaction notes

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