Acetone → 2,5-Difluoroanisole

HRID 428835Notes

Reaction equation

HRID 428835 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[CH3:10]C(C)=O.C(=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH3:10]

Participants

6

Reactant 4

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 949522,5-Difluorophenol

Product 1

HCID 27249892,5-Difluoroanisole

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

35.0 g of the product of Step A, 350 ml of acetone, 44.6 g of potassium carbonate and 40.7 g of dimethyl sulfate (neutralized on potassium bicarbonte) and was allowed to return to ambient temperature. Water was added and extraction was carried out with ether. The extracts were washed, dried and concentrated to dryness under reduced pressure to obtain 39.8 g of the desired product.

Workup

  1. customto return to ambient temperature
  2. extractionextraction
  3. washThe extracts were washed
  4. customdried
  5. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-85bf43347afd4681b4f09c3276b2b80c
Source dataset
uspto-grants-2001_11
Patent number
US06313305B1

Reaction notes

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