反应详情

A solution of 2,4-dichloro-quinazoline (15 g), N,N-diisopropyl-ethylamine (24.9 ml) and aniline (7.5 ml) in isopropanol (75 ml) is heated to reflux for 45 min. The cold reaction mixture is filtered and the filtrate is concentrated in vacuo. The residue is crystallized from diethylether-toluene (1:1) to give 2-chloro-4-phenylamino-quinazoline, m.p. 194-196° C.

1. temperatureto reflux for 45 min
2. customThe cold reaction mixture
3. filtrationis filtered
4. concentrationthe filtrate is concentrated in vacuo
5. customThe residue is crystallized from diethylether-toluene (1:1)