反应详情

温度

50 °C

To a suspension of 2,5-dichloro-4-nitroaniline (4.0 g, 19.3 mmol) in ethanol (50 ml) was added concentrated hydrochloric acid (20 ml) and water (20 ml). The mixture was heated to 50° C. and 27.5% hydrogen peroxide (6 ml) added over 15 min. The mixture was maintained at this temperature for a further 2 h, cooled to room temperature, and the solid filtered and washed with water (2×20 ml) to give the title compound (D11) (4.1 g, 88%), MH+ 241/243.

1. temperatureThe mixture was maintained at this temperature for a further 2 h
2. temperaturecooled to room temperature
3. filtrationthe solid filtered
4. washwashed with water (2×20 ml)