Hydrazine hydrate (1:1) → HCID 178434553, compound

HRID 429273Notes

Reaction equation

HRID 429273 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:19])[C:11](=[CH:15]OCC)[C:12]([CH3:14])=O)=[CH:5][CH:4]=1.O.[NH2:23][NH2:24]>C(O)C>[CH3:14][C:12]1[C:11]([C:10]([NH:9][C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:21])([F:20])[F:1])=[CH:4][CH:5]=2)=[O:19])=[CH:15][NH:24][N:23]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 534242632-(Ethoxymethylidene)-3-oxo-N-[4-(trifluoromethyl)phenyl]butanamide

Product 1

HCID 178434553HCID 178434553, compoundYield 33.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-[4-(Trifluoromethyl)phenyl]-2-(ethoxymethylene)acetoacetamide (1 g) in 3 mL of ethanol is stirred overnight with 0.3 g of hydrazine hydrate. The precipitate is collected by vacuum filtration, washed with ethanol:water 2:1 and dried to give 0.3 g of 3-methyl-4-[4-(trifluoromethyl)phenylaminocarbonyl]pyrazole as an off-white solid.

Workup

  1. filtrationThe precipitate is collected by vacuum filtration
  2. washwashed with ethanol:water 2:1
  3. customdried

Sources & evidence

ORD record
ord-97af3a390b1c41d88dd2e5f11f294d31
Source dataset
uspto-grants-2001_11
Patent number
US06316479B1

Reaction notes

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