Hydrochloric Acid → HCID 69963140, compound

HRID 429454Notes

Reaction equation

HRID 429454 reaction equation
C[O:2][C:3](=[O:29])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C@H:12]2[C:21]3[C:16](=[CH:17][C:18]([OH:22])=[CH:19][CH:20]=3)[O:15][CH2:14][C@H:13]2[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:8][CH:7]=1.Cl>[OH-].[K+].CO>[OH:22][C:18]1[CH:17]=[C:16]2[C:21]([C@H:12]([C:9]3[CH:8]=[CH:7][C:6]([O:5][CH2:4][C:3]([OH:29])=[O:2])=[CH:11][CH:10]=3)[C@H:13]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:14][O:15]2)=[CH:20][CH:19]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69961800HCID 69961800, compound

Product 1

HCID 69963140HCID 69963140, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14797Potassium HydroxideSolvent

Procedure

(+,−) cis [4-(7-Hydroxy-3-phenyl-chroman-4-yl)-phenoxy]-acetic acid methyl ester (30 mg, 0.077 mmol) was stirred in 2N potassium hydroxide in methanol (1 ml) for 120 min. The reaction mixture was acidified by 1 N hydrochloric acid (2.5 ml), and stirring continued for 60 min. The precipitated product was filtered, washed with water and vacuum dried with sicapent (Merck) at 50° C. overnight.

Workup

  1. filtrationThe precipitated product was filtered
  2. washwashed with water and vacuum
  3. customdried with sicapent (Merck) at 50° C. overnight

Sources & evidence

ORD record
ord-546c2781d2ca4a358b0b62f041031f64
Source dataset
uspto-grants-2001_11
Patent number
US06316494B1

Reaction notes

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