HCID 131722991, compound → HCID 131722990, compound

HRID 429457Notes

Reaction equation

HRID 429457 reaction equation
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C@H:13]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][N:34]4[CH2:39][CH2:38][O:37][CH2:36][CH2:35]4)=[CH:27][CH:26]=3)[C@H:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:15][O:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>Cl.C(O)C.[Pd]>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C@H:13]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][N:34]4[CH2:39][CH2:38][O:37][CH2:36][CH2:35]4)=[CH:27][CH:26]=3)[C@H:14]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:15][O:16]2)=[CH:11][CH:10]=1

Participants

5

Reactant 1

HCID 131722991HCID 131722991, compound

Product 1

HCID 131722990HCID 131722990, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

(+,−) cis 7-Benzyloxy-4-[4-(morpholinoethyloxy)-phenyl]-3-phenyl-chroman (139 mg, 0.27 mmol) was dissolved in a solution of 1% hydrochloride in ethanol (5 ml). The solution was added to a 10% palladium on carbon catalyst, and hydrogenated (1 atm.) overnight. The reaction mixture was filtered and evaporated. The evaporated product was dissolved in acetone and evaporated to give a glassy solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated
  3. dissolutionThe evaporated product was dissolved in acetone
  4. customevaporated
  5. customto give a glassy solid

Sources & evidence

ORD record
ord-1eed9305be0b4f22a9afc4b98c7be710
Source dataset
uspto-grants-2001_11
Patent number
US06316494B1

Reaction notes

Loading…