反应详情

To a solution of 2,4-dinitroaniline (2.2 g, 12 mmol) in 40 ml of AcOH was added 1.0 ml of Br2 dropwise and reaction mixture was stirred for 1 h. The reaction mixture was concentrated in vacua, yielding a dark residue which was diluted with EtOAc and washed with aqueous NaHCO3. Organic layer was dried over MgSO4 and concentrated in vacuo to provide 2.9 g (11 mmol, 92%) of 2,4-dinitro-6-bromo-aniline which was characterized by NMR and used in a following reaction without further purification.

1. customreaction mixture
2. concentrationThe reaction mixture was concentrated in vacua
3. customyielding a dark residue which
4. washwashed with aqueous NaHCO3
5. dry with materialOrganic layer was dried over MgSO4
6. concentrationconcentrated in vacuo