Hydrochloric Acid → HCID 69547913, compound

HRID 429750Notes

Reaction equation

HRID 429750 reaction equation
C(OC([NH:8][C@H:9]([C:16]([N:18]1[CH2:43][CH2:42][CH2:41][C@H:19]1[C:20]([NH:22][CH2:23][C:24]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[O:25])=[O:21])=[O:17])[CH2:10][C:11]1[N:12]=[CH:13][S:14][CH:15]=1)=O)(C)(C)C.[ClH:44]>C(OCC)(=O)C>[ClH:44].[S:14]1[CH:15]=[C:11]([CH2:10][C@@H:9]([C:16]([N:18]2[CH2:43][CH2:42][CH2:41][C@H:19]2[C:20]([NH:22][CH2:23][C:24]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[O:25])=[O:21])=[O:17])[NH2:8])[N:12]=[CH:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54470145HCID 54470145, compound

Product 1

HCID 69547913HCID 69547913, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of the compound (13) (1.2 g, 1.92 mmol) in ethyl acetate (20 ml) was added the solution of 4N-hydrogen chloride in ethyl acetate (20 ml) under ice-cooling and the resulting mixture was stirred for 2 h at the same temperature. The reaction mixture was concentrated in vacuo to give the compound (16) (1.27 g, quantitative). This compound used in the next, reaction without purification.

Workup

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-155e1c0e22c8407b8da784ed465e1367
Source dataset
uspto-grants-2001_11
Patent number
US06319902B1

Reaction notes

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