反应详情

96.3 g (366 mmoles) of benzylisothiocyanate were dissolved in 100 ml o THF and treated with 44.2 ml (732 mmoles) of 32% ammonia solution After 0.5 hour at 40-45° C., 300 ml of water were added and the THF removed in vacuo. The gummy suspension is treated with 200 ml of ether, the crystals collected and washed with water and ether. Suspension in 30 ml of methylenechloride and collection gave 65.77 g (64.2%) of benzyl-2-thiourea with mp 144-5° C.

1. customthe THF removed in vacuo
2. additionThe gummy suspension is treated with 200 ml of ether
3. customthe crystals collected
4. washwashed with water and ether
5. customSuspension in 30 ml of methylenechloride and collection