反应详情

0.250 g (1.23 mmol) of 3-methyl-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid were initially charged in approx. 12 ml of dichloromethane, and admixed under argon with 2 drops of dimethylformamide. 0.453 g (3.56 mmol) of oxalyl chloride were added dropwise and, after the end of the addition, the mixture was stirred at room temperature for 1 h. The solution was concentrated and the residue was admixed with approx. 10 ml of toluene and concentrated. This gave a colourless solid which was converted further immediately.

1. additionafter the end of the addition
2. concentrationThe solution was concentrated
3. concentrationconcentrated
4. customThis gave a colourless solid which