反应详情

8.2 ml of methyl iodide is added to 10 g of 3-chlorosalicylic acid and 18 g of potassium carbonate in 88 ml of dimethylformamide, and the mixture is stirred overnight. It is diluted with water, extracted with ethyl acetate, the organic phase is dried (Na2SO4) and concentrated by evaporation. The residue is distilled on a bulb tube. 10 g of 3-chloro-2-methoxybenzoic acid methyl ester is obtained, boiling point 100° C./0.17 mbar.

1. extractionextracted with ethyl acetate
2. dry with materialthe organic phase is dried (Na2SO4)
3. concentrationconcentrated by evaporation
4. distillationThe residue is distilled on a bulb tube