Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride

HRID 430593Notes

Reaction equation

HRID 430593 reaction equation
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7])#[N:2].C(Cl)(=O)C([Cl:18])=O>CN(C)C=O.C(Cl)Cl>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:18])=[O:7])#[N:2]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 18417533195532-64-0

Product 1

HCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

111 g of 3-cyano-2,4,5-trifluoro-benzoic acid, 84 g of oxalyl chloride and a few drops of dimethylformamide in 930 ml of dry methylene chloride are stirred at room temperature for 5 hours. The reaction mixture is concentrated by evaporation and the residue is distilled in vacuo.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. distillationthe residue is distilled in vacuo

Sources & evidence

ORD record
ord-2b89adf6c891449e8baa063d8a6962d8
Source dataset
uspto-grants-2001_11
Patent number
US06323213B1

Reaction notes

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