Water → HCID 18351368, compound

HRID 430604Notes

Reaction equation

HRID 430604 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([N:13]2[CH2:18][CH2:17][CH:16]([NH:19][CH3:20])[CH2:15][CH2:14]2)=O)=[CH:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].O.[OH-].[Na+]>O1CCCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][N:13]2[CH2:14][CH2:15][CH:16]([NH:19][CH3:20])[CH2:17][CH2:18]2)=[CH:2]1

Participants

6

Reactant 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 18351300HCID 18351300, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 18351368HCID 18351368, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7.2 g of the product obtained in Step C are added to a suspension of 2 g of LiAlH4 in 210 ml of tetrahydrofuran. After 48 hours at room temperature, the reaction mixture is hydrolysed with 1.4 ml of water, 1.1 ml of 20% sodium hydroxide solution and 5 ml of water. After filtration and concentration, chromatography over silica gel enables the expected product to be isolated.

Workup

  1. filtrationAfter filtration and concentration, chromatography over silica gel
  2. customto be isolated

Sources & evidence

ORD record
ord-3a1cfbdf1aa84912af1b2d4d18f38d32
Source dataset
uspto-grants-2001_11
Patent number
US06323217B2

Reaction notes

Loading…